A wearable sensor printed on pure polymer for monitoring physique fluids current in sweat

A wearable sensor printed on microbial nanocellulose, a pure polymer, has been created in Brazil by researchers on the College of São Paulo (USP) in São Carlos in collaboration with colleagues at São Paulo State College (UNESP) in Araraquara, the College of Araraquara (UNIARA), the College of Campinas (UNICAMP), and the Brazilian Nationwide Nanotechnology Laboratory (LNNano).

The skin-adherent sensor is an improved substitute for standard sensors printed on plastic surfaces. It may be used for noninvasive detection and monitoring of physique fluids current in sweat.

The examine was led by Osvaldo Novais de Oliveira Junior and supported by FAPESP by way of the initiatives “Printed and implantable biosensors constructed from biopolymers for long-term monitoring”, “Design and fabrication of nanostructured versatile gadgets for biomarker detection” and “Improvement of analytical instruments based mostly on digital tongues for simultaneous detection of bacterial threats”, in addition to a Multiuser Gear grant.

The article titled “Microbial nanocellulose adherent to human pores and skin utilized in electrochemical sensors to detect steel ions and biomarkers in sweat” is printed within the journal Talanta.

Microbial nanocellulose is a 100% pure polymer. It’s produced by micro organism from sugar. Its important benefit over plastic is its much better interface with human pores and skin. It has been commercially obtainable for some years to be used in wound dressings, amongst different purposes, nevertheless it had by no means earlier than been studied as an electrochemical sensor substrate.”

Robson Rosa da Silva, co-first writer of the article

One of many issues with wearable sensors on plastic substrates is that perspiration kinds a barrier between the pores and skin and sensor, hindering detection and selling allergic reactions. “Nanocellulose is completely breathable, enabling sweat to succeed in the electrode’s lively layer,” Silva mentioned.

The sensor is a small adhesive rectangle 1.5 cm in size by 0.5 cm in width and is as skinny as a sheet of tissue paper. It may well detect a variety of biomarkers, akin to sodium, potassium, uric acid, lactic acid and glucose, amongst others. “These components or substances flow into within the bloodstream and are additionally detectable in sweat. Subsequently, diabetes monitoring is one potential software of the nanocellulose sensor. One other is hormone management in ladies by way of detection of the hormone estradiol,” Silva mentioned.

The gadget will also be used to detect the presence of atmospheric pollution in organisms. “As proof of idea, we uncovered the sensor to low ranges of poisonous metals akin to lead and cadmium, and the consequence was constructive,” he mentioned.

The detection items are printed on the microbial nanocellulose substrate utilizing a semiautomatic display screen printer and a paste with a excessive focus of carbon particles. Carbon is most popular owing to its important electrical conductivity. “Chemical oxidation-reduction reactions produce {an electrical} sign that measures the focus of the metabolite of curiosity,” defined Paulo Augusto Raymundo Pereira, the opposite co-first writer of the article.

“The sensor is related to a potentiostat that makes electrochemical measurements by way of variations within the electrical present. The information obtained are transmitted to a pc and transformed into normal curves.”

In accordance with Pereira, wi-fi communication between the sensor and a knowledge measuring and studying gadget can simply be engineered.

The researchers at the moment are finding out the usage of the sensor to manage medicine and are engaged on methods of constructing it commercially possible. The primary part of the undertaking “Fabrication of display screen printed electrodes on biodegradable substrates (nanocellulose and onion movies Allium cepa L.) for medical, meals and agroindustrial purposes”, carried out by Biosmart Nanotechnology, was supported by FAPESP’s Modern Analysis in Small Enterprise (PIPE) Program.


São Paulo Analysis Basis (FAPESP)

Journal reference:

R. Silva, R., et al. (2020) Microbial nanocellulose adherent to human pores and skin utilized in electrochemical sensors to detect steel ions and biomarkers in sweat. Talanta.

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