First human scientific trial validates the practicality, accuracy of oxygen-sensing liquid bandage

Within the first human scientific trial, researchers at Massachusetts Common Hospital (MGH) and surgeons at Beth Israel Deaconess Medical Heart (BIDMC) have validated the practicality and accuracy of an oxygen-sensing liquid bandage that measures the focus of oxygen in transplanted tissue. The trial, revealed in Science Advances, in contrast the efficiency of a novel, paint-on bandage made with phosphorescent supplies to a wired tissue oximeter (ViOptix gadget) — the present normal for monitoring tissue oxygenation — in girls present process breast reconstruction surgical procedure after most cancers.

Our trial confirmed that the clear liquid bandage detected tissue oxygenation in addition to the gold normal of an oximeter, which makes use of previous expertise, is uncomfortable for the affected person, obstructs visible inspection of the tissue, and can provide false readings primarily based on lighting situations and the affected person’s actions. The standalone bandage is a significant development from a wired oximeter that restricts a affected person’s actions and is sophisticated to make use of.”

Conor L. Evans, PhD, paper’s senior writer and principal investigator at MGH’s Wellman Heart for Photomedicine

The analysis staff took on the problem of constructing a greater tissue oxygenation sensor following a request from the Division of Protection searching for to scale back failure charges of tissue transplant surgical procedures and pores and skin grafts in injured troopers. The expertise underlying the bandage was developed by way of the assist of the Navy Medical Photonics Program. The trial assessments the bandage in breast reconstruction, a standard kind of free-flap transplant surgical procedure wherein plastic surgeons harvest pores and skin, fats, arteries and blood vessels from the affected person’s stomach and microsurgically reattach the tissue and vessels to the chest.

“As much as 5% of free-flap surgical procedures can fail, usually inside 48 hours after surgical procedure, if blood circulation to the transplanted tissue is interrupted or insufficient, which is a devastating final result,” says Samuel J. Lin, MD, MBA, plastic and reconstructive surgeon at BIDMC and senior writer. By monitoring how a lot oxygen will get to the transplanted tissue, surgeons can shortly detect a vascular drawback and intervene to avoid wasting the transplant.

5 girls present process breast reconstruction have been enrolled within the trial from March to September 2017. The liquid bandage was painted on in a 1 cm by 1 cm space on seven transplanted flaps (two girls had each breasts reconstructed). A wired oximeter was additionally positioned on every flap, and tissue oxygenation was monitored for 48 hours after surgical procedure. The bandage measures the quantity of oxygen attending to the tissue itself, whereas the ViOptix reads the quantity of oxygen saturation within the blood with near-infrared spectroscopy–a much less direct measurement of essential blood circulation to the transplant.

On this research, a clinician-researcher took images of the bandage with a digital digicam with customized filters following surgical procedure. The flash from the digicam excited the phosphorescent materials within the bandage, which then glowed pink to inexperienced primarily based on the quantity of oxygen current within the tissue. Evans and colleagues have since developed a battery-powered sensor head for the bandage that eliminates the necessity for the digicam and makes the bandage self-contained. The prototype research was revealed in Biomedical Optics Categorical.

In all seven flaps, the tissue oxygenation price of change measured by the bandage correlated with the oximeter, and all seven flaps have been profitable. The researchers are at the moment designing a scientific trial to review how properly the bandage detects a flap that’s failing from lack of oxygen.

“The power to have a wi-fi oxygen monitoring gadget for blood circulation is probably a gamechanger,” says Lin.

Scientific functions for an oxygen-sensing bandage might embody monitoring wound therapeutic, tissue transplants for trauma, pores and skin grafts for burns, limbs affected by peripheral artery illness and continual ischemia (diminished blood circulation). “The expertise may additionally detect necessary tissue adjustments in sufferers with coronary heart illness and different continual medical situations, offering an early warning sign that illness is progressing,” says Lin. “And there are probably different scientific makes use of we have not but thought of.”


Journal reference:

Marks, H., et al. (2020) A paintable phosphorescent bandage for postoperative tissue oxygen evaluation in DIEP flap reconstruction. Science Advances.

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