Hyperbaric oxygen remedies in wholesome adults can reverse the growing old course of, finds examine

A brand new examine from Tel Aviv College (TAU) and the Shamir Medical Heart in Israel signifies that hyperbaric oxygen remedies (HBOT) in wholesome growing old adults can cease the growing old of blood cells and reverse the growing old course of. Within the organic sense, the adults’ blood cells truly develop youthful because the remedies progress.

The researchers discovered {that a} distinctive protocol of remedies with high-pressure oxygen in a strain chamber can reverse two main processes related to growing old and its sicknesses: the shortening of telomeres (protecting areas positioned at each ends of each chromosome) and the buildup of previous and malfunctioning cells within the physique. Specializing in immune cells containing DNA obtained from the members’ blood, the examine found a lengthening of as much as 38% of the telomeres, in addition to a lower of as much as 37% within the presence of senescent cells.

The examine was led by Professor Shai Efrati of the Sackler Faculty of Medication and the Sagol Faculty of Neuroscience at TAU and Founder and Director of the Sagol Heart of Hyperbaric Medication on the Shamir Medical Heart; and Dr. Amir Hadanny, Chief Medical Analysis Officer of the Sagol Heart for Hyperbaric Medication and Analysis on the Shamir Medical Heart. The scientific trial was performed as a part of a complete Israeli analysis program that targets growing old as a reversible situation.

The paper was printed in Growing old on November 18, 2020.

For a few years our group has been engaged in hyperbaric analysis and remedy – remedies based mostly on protocols of publicity to high-pressure oxygen at numerous concentrations inside a strain chamber. Our achievements over time included the development of mind features broken by age, stroke or mind harm.

Within the present examine we wished to look at the affect of HBOT on wholesome and unbiased growing old adults, and to find whether or not such remedies can decelerate, cease and even reverse the conventional growing old course of on the mobile stage.”

Professor Shai Efrati, Sackler Faculty of Medication and the Sagol Faculty of Neuroscience at TAU

The researchers uncovered 35 wholesome people aged 64 or over to a collection of 60 hyperbaric periods over a interval of 90 days. Every participant offered blood samples earlier than, throughout and on the finish of the remedies in addition to a while after the collection of remedies concluded. The researchers then analyzed numerous immune cells within the blood and in contrast the outcomes.

The findings indicated that the remedies truly reversed the growing old course of in two of its main elements: The telomeres on the ends of the chromosomes grew longer as an alternative of shorter, at a price of 20%-38% for the completely different cell sorts; and the share of senescent cells within the general cell inhabitants was diminished considerably – by 11%-37% relying on cell kind.

“In the present day telomere shortening is taken into account the ‘Holy Grail’ of the biology of growing old,” Professor Efrati says. “Researchers around the globe try to develop pharmacological and environmental interventions that allow telomere elongation. Our HBOT protocol was in a position to obtain this, proving that the growing old course of can in reality be reversed on the fundamental cellular-molecular stage.”

“Till now, interventions equivalent to way of life modifications and intense train have been proven to have some inhibiting impact on telomere shortening,” Dr. Hadanny provides. “However in our examine, solely three months of HBOT have been in a position to elongate telomeres at charges far past any at the moment obtainable interventions or way of life modifications. With this pioneering examine, we’ve got opened a door for additional analysis on the mobile affect of HBOT and its potential for reversing the growing old course of.”


Journal reference:

Hachmo, Y., et al. (2020) Hyperbaric oxygen remedy will increase telomere size and reduces immunosenescence in remoted blood cells : a potential trial. Growing old. old.202188.

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