New analysis provides hope for treating Parkinson’s illness

The American Academy of Neurology (AAN) has printed, on August 12, the outcomes of a analysis venture carried out collectively by Cardiocentro Ticino and the EOC Neurocentro, which delivers a message of hope within the battle in opposition to Parkinson’s illness, in addition to offering encouraging information for the USI School of Biomedical Sciences.

The research focuses on the evaluation of blood plasma microvesicles (exosomes), which might permit the illness to be detected at a really early stage, favouring simpler therapeutic approaches. The brand new methodology, non-invasive and economical, requires a easy blood pattern.

The analysis was made doable by a detailed collaboration between the laboratories of the Neurocentro of the Ente Ospedaliero Cantonale (EOC) and Cardiocentro Ticino – each of that are immediately concerned within the coaching actions of the School of Biomedical Sciences of the UniversitĂ  della Svizzera italiana (USI).

The analysis venture is the topic of the thesis work of Elena Vacchi, PhD pupil in Neuroscience at USI, and Jacopo Burrello, visiting PhD pupil on the College of Turin at Cardiocentro.

In direction of an early testing of the illness

As we speak, the analysis of Parkinson’s illness happens at a sophisticated stage of its medical manifestations, a limitation that considerably impacts the therapeutic method.

The evaluation of exosomes in plasma – as confirmed by research carried out within the laboratories in Ticino – might prepared the ground to an early testing of the illness, at a stage during which the inflammatory course of that originates it’s already occurring.

Because the researchers level out, it is a revolutionary method to the analysis of Parkinson’s illness. It is usually a completely non-invasive, painless and cheap methodology, because it requires a easy peripheral blood pattern.

The research and the collaboration community

The research, printed in Neurology: Neuroimmunology & Neuroinflammation, a journal of the American Academy of Neurology, was collectively carried out by the Parkinson’s analysis group headed by PD Dr. med. Giorgia Melli and Prof. Dr. med. Alain Kaelin on the Laboratory of Biomedical Neuroscience (LBN) of the EOC Neurocentro in Taverne and the Cardiocentro Ticino analysis group directed by PD Dr. Lucio Barile in collaboration with Prof. Giuseppe Vassalli.

Apart from the scientific worth of the analysis and our satisfaction for the popularity. I believe it is very important replicate on the added worth of a synergy between apparently distant analysis fields – neurology and cardiology – which nonetheless handle to search out unique and really fascinating developments within the every day and clear comparability of their respective works, a situation that has been positively achieved in recent times in our joint laboratories in Taverne.”

Dr med Alain Kaelin, Professr and Medical and Scientific Director, Neurocentro EOC

Dr Alain si additionally a full professor at USI.


Journal reference:

Vacchi, E., et al. (2020) Immune profiling of plasma-derived extracellular vesicles identifies Parkinson illness. Neurology: Neuroimmunology & Neuroinflammation.

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