Xiaowei Dong, Affiliate Professor and P1 Curriculum Director at HSC School of Pharmacy, was lately awarded the Maximizing Investigators’ Useful resource Award (MIRA-R35) to proceed her analysis into applied sciences that enhance the effectiveness of oral medication.
Dr. Dong acquired the five-year, $1.eight million award from Nationwide Institutes of Normal Medical Sciences on the Nationwide Institutes of Well being.
An estimated 40% of permitted medication and almost 90% of the developmental pipeline medication include poorly water-soluble molecules, Dr. Dong mentioned. Oral administration is essentially the most favorable and most well-liked route.
Beforehand, Dr. Dong labored as a lead formulator in drug product growth at Novartis Pharmaceutical Company, the place her initiatives have been associated to water-insoluble compounds.
“Though there have been a number of oral particular supply programs accessible for water-insoluble compounds, we nonetheless confronted restricted expertise choices,” she mentioned. “With out efficient drug supply programs for poorly water-soluble medication, growth of oral formulations of molecules are sometimes deserted nonetheless having robust therapeutic potentials.
“Furthermore, many marketed oral medication have poor water solubility and are generally related to low bioavailability and affected person variability.”
As an skilled in lipid nanoparticles, Dr. Dong noticed their benefits for drug supply. Nevertheless, a hurdle in utilizing lipid nanoparticles in oral stable dosage varieties was low drug loading, that means the ultimate stable kind would have a small quantity of drug after nanoparticles have been transformed to stable varieties.
“After I got here again to academia in 2013, I devoted myself to analysis on this space. In 2015, I found in situ self-assembled nanoparticles (ISNP),” Dr. Dong mentioned.
This award is predicated on this nanotechnology to advance formulation expertise for water-insoluble medication, she mentioned.
“With this novel nanotechnology, we’re capable of produce drug stable nanoformulations with excessive drug loading,” Dr. Dong mentioned. “We discovered many particular options about this nanotechnology.”
Dr. Dong, who earned a PhD in Pharmaceutical Sciences in School of Pharmacy on the College of Kentucky, collaborates with different analysis efforts.
“The ISNP nanotechnology is the principle focus in my lab now,” she mentioned. “(However) as a result of my analysis is about formulation expertise, I can use it for various medication to deal with totally different illnesses. Presently, I collaborate with different researchers on the therapies of lung illness, cancers and diabetes.”
Dr. Dong mentioned analysis on formulation and drug supply is inventive work.
“We have to customise every formulation in line with the properties of 1 explicit drug,” she mentioned. “This analysis can also be very difficult as a result of we have now to always change compositions, expertise and procedures to supply the very best formulation for one drug.”