Revolutionary Remedy Offers Hope For the Chronically Sick

Low dose naltrexone has not too long ago garnered consideration as a potential remedy for autoimmune ailments, neurological circumstances, most cancers and another sicknesses. Naltrexone is an opiate antagonist, which implies that it blocks opioid receptors within the mind and thus eliminates the sensation of delight attributable to e.g. consuming alcohol, as a result of our endogenous opioids (endorphins) can’t bind to the receptors. However when utilized in very small doses (lower than 1/10 of the conventional dose) naltrexone can be utilized to stimulate the discharge of endorphins.

Historical past

Low dose naltrexone was pioneered by the neurologist Bernard Bihari within the early Eighties, when he was learning medicines used for drug and alcohol withdrawal. He seen that very small doses of naltrexone (initially 3 mg) taken at bedtime solely blocked the opioid receptors transiently, which stimulated the physique to supply extra of its endogenous opioids and produced no important uncomfortable side effects.

Bihari tried LDN as a remedy for HIV/AIDS and a number of sclerosis, two circumstances which were proven to be related to low ranges of beta endorphin, probably the most vital endogenous opioids. In a few of his AIDS sufferers the blood ranges of beta endorphin as a lot as tripled when utilizing low dose naltrexone.

Sufferers additionally skilled marked medical enchancment. The MS signs (particularly fatigue) had been relieved and the sickness development appeared to halt. Most sufferers by no means skilled a single MS assault after the initiation of low dose naltrexone. Sufferers contaminated with HIV had their viral counts drop radically and their CD4 counts subsequently went up. Because of this the charges opportunistic infections and AIDS associated malignancies decreased.

Later improvement

Inspired by his success Bihari and different medical doctors started making an attempt LDN for different circumstances, reminiscent of different autoimmune sicknesses and most cancers, usually with nice outcomes. The assist from the affected person group has been overwhelming. Sufferers with MS have collected cash for medical trials and there have even been three conferences on LDN and the fourth one is scheduled for October 2008.

A examine revealed within the American Journal of Gastroenterology discovered that 89% of sufferers with Crohn’s illness had been improved on LDN and 67% achieved a full remission. There are medical trials at present working for a number of sclerosis, Crohn’s illness, autism, fibromyalgia, pancreatic most cancers and squamous cell carcinoma of the top and neck (head and neck most cancers). A big HIV/AIDS examine can be working in Mali, West Africa.

Diseases that may be handled with LDN

LDN has been efficiently used to deal with the next circumstances:

Autoimmune ailments

  • a number of sclerosis
  • systemic lupus erythematosus (SLE/LED)
  • rheumatoid arthritis
  • ankylosing spondylitis
  • pemphigoid
  • sarcoidosis
  • scleroderma
  • Crohn’s illness
  • ulcerative colitis
  • celiac illness
  • psoriasis and psoriatic arthritis
  • Wegener’s granulomatosis
  • transverse myelitis


  • bladder most cancers
  • breast most cancers
  • carcinoid tumor
  • colorectal most cancers
  • glioblastoma
  • liver most cancers
  • non-small cell lung most cancers (NSLC)
  • power lymphocytic leukemia
  • lymphoma (each Hodgkin’s and non-Hodgkin’s)
  • melanoma
  • a number of myeloma
  • neuroblastoma
  • ovarian most cancers
  • pancreatic most cancers
  • prostate most cancers
  • renal cell carcinoma
  • throat most cancers
  • uterine most cancers

Different sicknesses

  • hepatitis C
  • amyotrophic lateral sclerosis (ALS)/major lateral sclerosis (PLS)
  • autism
  • Alzheimer’s illness
  • Parkinson’s illness
  • Behcet’s illness
  • power obstructive pulmonary illness (COPD, emphysema)
  • endometriosis
  • fibromyalgia
  • power fatigue syndrome/myalgic encephalomyelitis (CFS/ME)
  • irritated bowel syndrome (IBS)

LDN could presumably additionally work for e.g. myasthenia gravis, antiphospholipid syndrome/Hughes syndrome, narcolepsy (a presumably autoimmune situation), interstitial cystitis, power Lyme illness/put up Lyme syndrome, zits, rosacea, power urticaria, dementia, obsessive-compulsive dysfunction (OCD), cluster complications, schizophrenia and post-traumatic stress dysfunction (PTSD). It has been reported to be useful in insomnia and migraine prevention.

Mode of motion

Endorphins are sometimes related to the nice feeling we get from e.g. train, however they’re extra than simply that. Beta endorphin and met enkephalin, one other opioid peptide produced by the physique have profound results on the immune system. Quite a few animal research have demonstrated that met enkephalin acts as an anti-cancer agent. Beta endorphin ranges have proven to be low in HIV/AIDS, many autoimmune circumstances and e.g. migraine.

Autoimmune sicknesses have been historically seen as manifestations of an overactive immune system and are normally handled with immunosuppressants, however an increasing number of information is rising that means that autoimmune circumstances could the truth is be types of immunedeficiency, explaining why LDN, an immunostimulant, works for them.

Medical results

In most autoimmune ailments the illness development halts. Signs, reminiscent of fatigue, ache, muscle weak spot and cognitive issues are sometimes alleviated, as nicely. In degenerative circumstances like ALS and Alzheimer’s the sickness development is slowed down. The lipodystrophy attributable to antiretroviral (HIV) medication normally improves considerably.

Bihari stories {that a} halt in most cancers progress happens in about 50% of the most cancers sufferers he treats. A few of these sufferers present goal indicators of tumor shrinkage. Some sufferers who’ve been deemed terminal with little time left are nonetheless alive and doing nicely years later, reminiscent of one with pancreatic most cancers (one of many deadliest cancers) whose case was revealed in Integrative Most cancers Therapies.

Based on Bihari LDN works greatest for the next cancers: a number of myeloma, Hodgkin’s illness, breast most cancers, cancers of the gastrointestinal tract (together with the pancreas) and non-small cell lung most cancers. That is not to say that most cancers sufferers ought to ditch their current remedies, however LDN will be mixed with chemotherapy and radiotherapy. Some sufferers solely bear surgical procedure or are thought-about to not profit from typical remedy, so they might be good candidates for LDN.

How it’s used

LDN is taken each night time between 9 PM and three AM, because the physique produces most of its endorphins throughout the early morning hours. There are normally no uncomfortable side effects. Some folks expertise issues with sleeping throughout the first week. Nausea, feeling “excessive”, fuel and bloating and starvation pangs could happen at first and normally go away in just a few days. In sufferers with MS spasticity could transiently worsen. It could take anyplace between a day and some months to note enchancment.

LDN can safely be taken with all different medicines, meals or dietary supplements, however as a result of it’s an opiate antagonist it can’t be mixed with any narcotic painkillers (opiates), together with tramadol, and taking it with immunosuppressive medication (like corticosteroids) could trigger the medication to “cancel out” one another’s results, as LDN is an immunostimulant. The one contraindication is a previous organ transplant, as a result of taking an immunostimulant may result in graft rejection.

Any physician can prescribe LDN as an “ex tempore” prescription, to be crammed by a compounding pharmacy. Some folks use overseas pharmacies, as it’s authorized in most nations to order medicines from overseas with a legitimate prescription. LDN could also be formulated as capsules or liquid, however the liquid must be refrigerated and is much less handy when touring. It is strongly recommended that calcium carbonate is just not used as a filler for tablets.

The really helpful dose is 4.5 mg, however some folks, particularly those that are very slim and people with extreme MS, solely take 3 mg. Usually prescriptions are written for 1.5 mg capsules in order that the affected person can attempt taking both two or three directly. LDN can be comparatively cheap, normally costing between $15 and $40 a month.

Supply by Maija Haavisto

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