Three-year Indonesia trial produces encouraging outcomes for dengue management

A 3-year trial in Indonesia has produced encouraging outcomes that present a major discount within the variety of dengue circumstances. It concerned the discharge Wolbachia-infected Aedes aegypti mosquitoes in and across the dengue-endemic metropolis of Yogyakarta.

The examine discovered that within the metropolis and surrounding areas the place the contaminated mosquitoes have been launched the variety of circumstances of dengue decreased considerably in contrast with components of the town the place they weren’t.

The trial – carried out by the World Mosquito Program in shut collaboration with the Tahija Basis and the Gadjah Mada College in Indonesia – examined Ae. aegypti mosquitoes carrying Wolbachia for his or her capability to inhibit transmission of dengue virus.

The outcomes can be submitted for analysis throughout the subsequent assembly of the WHO Vector Management Advisory Group in December for consultants to formally assess the influence of the technique based mostly on the outcomes of the trial and related research.

As there are few efficient sustainable instruments obtainable to fight Aedes-borne ailments, all new instruments that exhibit public well being worth towards dengue and related viruses can be a welcome addition to the vector management arsenal.


Wolbachia are intercellular pure symbiotic micro organism in bugs which are identified to cut back the capability of Ae. aegypti to transmit dengue virus and associated viruses underneath laboratory situations. Nevertheless, epidemiological proof has been awaited to exhibit the massive‐scale deployment of Wolbachia-infected Ae. aegypti in decreasing the general frequency of transmission of dengue virus inside a inhabitants; the outcomes of the examine from Indonesia are due to this fact of nice curiosity.


Dengue is a mosquito-borne viral illness that has quickly unfold in all areas of WHO in recent times. The incidence of dengue has grown dramatically worldwide in current many years. The virus is transmitted by feminine mosquitoes primarily of the species Ae. aegypti and, to a lesser extent, Ae. albopictus.

The variety of dengue circumstances reported to WHO elevated greater than 8-fold over the previous 20 years, and dengue is the one communicable illness that has elevated exponentially with speedy urbanization and environmental modifications. The overwhelming majority of circumstances are asymptomatic or gentle and self-managed; therefore, the precise numbers of dengue circumstances are under-reported.

The world depends closely on vector management, and traditional strategies have restricted influence. Lack of funds for operational analysis and the paucity of sturdy proof for sustained interventions proceed to undermine world management efforts.

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